Alcohol uncaging with fluorescence reporting:: Evaluation of o-acetoxyphenyl methyloxazolone precursors

被引：42

作者：

Gagey, Nathalie ^{[1
]}

Emond, Matthieu ^{[1
]}

Neveu, Pierre ^{[1
,2
]}

Benbrahim, Chouaha ^{[1
]}

Goetz, Bernard ^{[1
]}

Aujard, Isabelle ^{[1
]}

Baudin, Jean-Bernard ^{[1
]}

Jullien, Ludovic ^{[1
]}

机构：

[1] UPMC Paris 06, ENS, CNRS, Dept Chim,UMR 8640, F-75231 Paris 05, France

[2] UPMC Paris 06 Paris 07, ENS, CNRS, Lab Phys Stat,UMR 8550, F-75231 Paris 05, France

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 12期

关键词：

D O I：

10.1021/ol800284g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper evaluates a series of photolabile protecting groups with built-in fluorescence reporting. They rely on readily available o-acetoxyphenyl methyloxazolones as activated precursors. Alcohol substrates are easily caged. The resulting photoactivable esters exhibit large one- and two-photon uncaging cross sections. The alcohol substrates are quantitatively released in a 1:1 molar ratio with a strongly fluorescent coumarin coproduct that serves as a reporter to quantify substrate delivery.

引用

页码：2341 / 2344

页数：4

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