The HCP5 single-nucleotide polymorphism:: A simple screening tool for prediction of hypersensitivity reaction to abacavir

被引：75

作者：

Colombo, Sara ^{[1
,2
]}

Rauch, Andri ^{[3
,4
]}

Rotger, Margalida ^{[1
,2
]}

Fellay, Jacques ^{[7
]}

Martinez, Raquel ^{[1
,2
]}

Fux, Christoph ^{[3
,4
]}

Thurnheer, Christine ^{[3
,4
]}

Guenthard, Huldrych F. ^{[5
,6
]}

Goldstein, David B. ^{[7
]}

Furrer, Hansjakob ^{[3
,4
]}

Telenti, Amalio ^{[1
,2
]}

机构：

[1] Univ Hosp Ctr, Inst Microbiol, Lausanne, Switzerland

[2] Univ Lausanne, Lausanne, Switzerland

[3] Univ Hosp Bern, Div Infect Dis, CH-3010 Bern, Switzerland

[4] Univ Bern, Bern, Switzerland

[5] Univ Zurich Hosp, Div Infect Dis, CH-8091 Zurich, Switzerland

[6] Univ Zurich Hosp, Hosp Epidemiol, CH-8091 Zurich, Switzerland

[7] Duke Univ, Duke Inst Genome Sci & Policy, Ctr Populat Genom & Pharmacogenet, Durham, NC USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 198卷 / 06期

关键词：

D O I：

10.1086/591184

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The HLA-B* 5701 allele is predictive of hypersensitivity reaction to abacavir, a response herein termed " ABC-HSR." This study of 1103 individuals infected with human immunodeficiency virus assessed the usefulness of genotyping a HCP5 single-nucleotide polymorphism ( SNP), rs2395029, in relation to ABC-HSR. In populations with European ancestry, rs2395029 is in linkage disequilibrium with HLA-B* 5701. The HCP5SNPwas present in all 98 HLA-B* 5701 -positive individuals and was absent in 999 of 1005 HLA-B* 5701 -negative individuals. rs2395029 was overrepresented in 25 individuals with clinically likely ABC-HSR, compared with its frequency in 175 ABC-tolerant individuals (80% vs. 2%, respectively; P<. 0001). Therefore, HCP5 genotyping could serve as a simple screening tool for ABC-HSR, particularly in settings where sequence-based HLA typing is not available.

引用

页码：864 / 867

页数：4

共 13 条

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