Single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system

被引：17

作者：

Aoi, M ^{[1
]}

Date, I ^{[1
]}

Tomita, S ^{[1
]}

Ohmoto, T ^{[1
]}

机构：

[1] Okayama Univ, Sch Med, Dept Neurol Surg, Okayama 7008558, Japan

来源：

NEUROLOGICAL RESEARCH | 2000年 / 22卷 / 08期

关键词：

Parkinsons disease; GDNF; dopamine regeneration;

D O I：

10.1080/01616412.2000.11740761

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor beta superfamily and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF at a dose of 100 mug was injected stereotactically into the striatum of Sprague-Dawley rats that had been treated with intrastriatal 6-hydroxydopamine (6-OHDA) injection four weeks earlier. Immunocytochemical and behavioral analyses showed significant recovery of the nigrostriatal dopaminergic system after a single GDNF injection or continuous GDNF injection. Immunocytochemical and behavioral study showed that there was no significant difference between the results obtained from the two different injection methods. This result demonstrates the potential usefulness of GDNF for the treatment of Parkinson's disease.

引用

页码：832 / 836

页数：5

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