FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression

被引:83
作者
Brinkmann, V
Chen, S
Feng, L
Pinschewer, D
Nikolova, Z
Hof, R
机构
[1] Novartis Pharma AG, Transplantat Res, CH-4002 Basel, Switzerland
[2] Scripps Res Inst, La Jolla, CA 92037 USA
[3] Univ Zurich, Inst Expt Immunol, CH-8091 Zurich, Switzerland
关键词
D O I
10.1016/S0041-1345(00)02126-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
[No abstract available]
引用
收藏
页码:530 / 531
页数:2
相关论文
共 12 条
  • [1] FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation
    Brinkmann, V
    Pinschewer, D
    Chiba, K
    Feng, LL
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2000, 21 (02) : 49 - 52
  • [2] Human safety and pharmacology of FTY 720
    Brunkhorst, R
    Neumayer, HH
    Hiss, M
    Budde, K
    Lucker, P
    Mayer, T
    Brookman, L
    Schmouder, R
    [J]. TRANSPLANTATION, 1999, 67 (07) : S153 - S153
  • [3] Chen SH, 2000, TRANSPLANTATION, V69, pS194
  • [4] Chiba K, 1998, J IMMUNOL, V160, P5037
  • [5] FTY720, a new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery disease in a murine model of cardiac transplantation
    Hwang, MW
    Matsumori, A
    Furukawa, Y
    Ono, K
    Okada, M
    Iwasaki, A
    Hara, M
    Sasayama, S
    [J]. CIRCULATION, 1999, 100 (12) : 1322 - 1329
  • [6] Kahan BD, 2000, TRANSPLANTATION, V69, pS132
  • [7] Human pharmacokinetics of FTY 720
    Neumayer, HH
    Brunkhorst, R
    Budde, K
    Hiss, M
    Lucker, P
    Mayer, T
    Choudhury, S
    Kraus, G
    Schmouder, R
    [J]. TRANSPLANTATION, 1999, 67 (07) : S204 - S204
  • [8] NIKOLOVA Z, IN PRESS TRANSPLANT
  • [9] FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory
    Pinschewer, DD
    Ochsenbein, AF
    Odermatt, B
    Brinkmann, V
    Hengartner, H
    Zinkernagel, RM
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (11) : 5761 - 5770
  • [10] QUESNIAUX V, IN PRESS TRANSPLANT