Biosynthesis of conjugatable saccharidic moieties of GM2 and GM3 gangliosides by engineered E-coli

被引：28

作者：

Fort, S ^{[1
]}

Birikaki, L ^{[1
]}

Dubois, MP ^{[1
]}

Antoine, T ^{[1
]}

Samain, E ^{[1
]}

Driguez, H ^{[1
]}

机构：

[1] Univ Grenoble 1, CNRS, CERMAV FR 2607, Ctr Rech Macromol Vegetales, F-38041 Grenoble, France

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 20期

关键词：

D O I：

10.1039/b500686d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oligosaccharidic moieties of GM(2) and GM(3) gangliosides bearing an allyl or a propargyl aglycon, are efficiently biosynthesized on the gram scale by growing metabolically engineered Escherichia coli cells in the presence of the corresponding lactoside acceptors and sialic acid.

引用

页码：2558 / 2560

页数：3

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