Rational design of a new series of pronucleotide

被引：17

作者：

Beltran, T

Egron, D

Pompon, A

Lefebvre, I

Périgaud, C

Gosselin, G

Aubertin, AM

Imbach, JL

机构：

[1] Univ Montpellier 2, UMR 5625 CNRS UM 11, F-34095 Montpellier 05, France

[2] Univ Strasbourg, Fac Med, Virol Lab, Unite 74 INSERM, F-67000 Strasbourg, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(01)00299-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new pronucleotide series is described involving a two-step degradation process mediated by. respectively, carboxylesterase and phosphoramidase. Taking AZT as nucleosidyl moiety, it is shown that most of the compounds inhibit HIV replication in TK- cell line, which proves 5'-AZTMP delivery. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：1775 / 1777

页数：3

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