Ca2+ and synaptic plasticity

被引：46

作者：

Chittajallu, R

Alford, S

Collingridge, GL

机构：

[1] Univ Bristol, Sch Med, Dept Anat, Bristol BS8 1TD, Avon, England

[2] Northwestern Univ, Sch Med, Dept Physiol, NW Univ Inst Neurosci, Chicago, IL 60611 USA

来源：

CELL CALCIUM | 1998年 / 24卷 / 5-6期

关键词：

D O I：

10.1016/S0143-4160(98)90061-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A major effort in neuroscience is directed towards understanding the roles of Ca2+ signalling in the induction of synaptic plasticity. Here, we summarize the evidence concerning Ca2+ signalling, paying particular attention to CA1 excitatory synapses, and its relationship to the induction of long-term potentiation and long-term depression. We discuss the ways in which synaptic activation can elevate Ca2+ postsynaptically and how dendritic spines may act as a Ca2+ compartment which can both isolate and integrate Ca2+ signals.

引用

页码：377 / 385

页数：9

共 79 条

[1] CHARACTERIZATION OF CA2+ SIGNALS INDUCED IN HIPPOCAMPAL CA1 NEURONS BY THE SYNAPTIC ACTIVATION OF NMDA RECEPTORS [J].