Ca2+ and synaptic plasticity

被引:46
作者
Chittajallu, R
Alford, S
Collingridge, GL
机构
[1] Univ Bristol, Sch Med, Dept Anat, Bristol BS8 1TD, Avon, England
[2] Northwestern Univ, Sch Med, Dept Physiol, NW Univ Inst Neurosci, Chicago, IL 60611 USA
关键词
D O I
10.1016/S0143-4160(98)90061-6
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A major effort in neuroscience is directed towards understanding the roles of Ca2+ signalling in the induction of synaptic plasticity. Here, we summarize the evidence concerning Ca2+ signalling, paying particular attention to CA1 excitatory synapses, and its relationship to the induction of long-term potentiation and long-term depression. We discuss the ways in which synaptic activation can elevate Ca2+ postsynaptically and how dendritic spines may act as a Ca2+ compartment which can both isolate and integrate Ca2+ signals.
引用
收藏
页码:377 / 385
页数:9
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