The involvement of an ATP-gated ion channel, P-2X1, in thymocyte apoptosis

被引:100
作者
Chvatchko, Y
Valera, S
Aubry, JP
Renno, T
Buell, G
Bonnefoy, JY
机构
[1] GENEVA BIOMED RES INST,DEPT MOL BIOL,CH-1228 GENEVA,SWITZERLAND
[2] LUDWIG INST CANC RES,LAUSANNE BRANCH,CH-1066 EPALINGES,SWITZERLAND
关键词
D O I
10.1016/S1074-7613(00)80322-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In the immune system, apoptosis is involved in intrathymic elimination of self-reactive thymocytes and in peripheral T cell tolerance to exogenous antigens. Here, we describe the role in T cell apoptosis of P-2x1, a nonselective cation channel activated by ATP. P-2x1 molecules are up-regulated in thymocytes during dexamethasone-induced apoptosis, and antagonists to these receptors protect thymocytes from cell death. Moreover, P-2x1 mRNA and protein levels increase in thymocytes induced to die in vivo by the superantigen staphylococcal enterotoxin B. In contrast, T cells undergoing apoptosis in the periphery do not express P-2x1. The demonstration that P-2x1 ion channels play a role in the apoptosis of thymocytes but not peripheral T cells illustrates a novel mechanism contributing to thymocyte cell death and opens new possibilities for investigating clonal deletion in the thymus.
引用
收藏
页码:275 / 283
页数:9
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