A novel class of inhibitors for steroid 5α-reductase:: Synthesis and evaluation of umbelliferone derivatives

被引：98

作者：

Fan, GJ

Mar, W

Park, MK

Choi, EW

Kim, K

Kim, S

机构：

[1] Seoul Natl Univ, Inst Nat Prod Res, Seoul 110460, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(01)00429-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of umbelliferone derivatives was prepared and their 5 alpha -reductase type 1 inhibitory activities were evaluated in cell culture systems. Our studies have identified a new series of potent 5 alpha -reductase type 1 inhibitors and provided the basis for further development for the treatment of human endocrine disorders associated,vith overproduction of DHT by 5 alpha -reductase type 1. The preliminary structure-activity relationship was described to elucidate the essential structural requirements. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：2361 / 2363

页数：3

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