Structure activity relationship study of known inhibitors of the enzyme 5α-reductase (5AR)

被引：7

作者：

Ahmed, S ^{[1
]}

Denison, S ^{[1
]}

机构：

[1] Kingston Univ, Sch Appl Chem, Surrey KT1 2EE, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(98)00044-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Preliminary results of a modelling study of both steroidal and non-steroidal inhibitors of 5 alpha-reductase (5AR) are described in order to elucidate the essential structural requirements needed for the design of novel non-steroidal inhibitors. The study suggests that : (i) there is a requirement for groups to mimic the C(3)=O of the steroid substrate A-ring; (ii) the area of the active site about the C(17)-OH position of the substrate does not appear to possess hydrogen bonding groups and is unrestricted. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：409 / 414

页数：6

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*TRIP ASS INC, ALCH 3 POW