INHIBITION OF STEROID 5-ALPHA-REDUCTASE BY INVERTED, COMPETITIVE INHIBITORS

被引：15

作者：

MCDONALD, IA

NYCE, PL

MUENCH, DM

GATES, CA

BLOHM, TR

LAUGHLIN, ME

WEINTRAUB, PM

机构：

[1] Marion Merrell Dow Research Institute, Cincinnati, OH 45215

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)80861-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Modified steroids, in which the D-ring has been converted to a six-membered ring lactam, were designed as inverted (or backward-binding), competitive inhibitors of steroid 5alpha-reductase.

引用

页码：847 / 851

页数：5

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