Kinetic evaluation of the size-dependent decomposition performance of solvent-free microcellular polylactic acid foams

被引:9
作者
Guo GePu [1 ]
Ma QingYu [1 ]
Wang Fang [2 ]
Zhao Bo [3 ]
Zhang Dong [4 ]
机构
[1] Nanjing Normal Univ, Sch Phys & Technol, Key Lab Optoelect Jiangsu Prov, Nanjing 210046, Jiangsu, Peoples R China
[2] Nanjing Normal Univ, Ctr Anal & Testing, Nanjing 210046, Jiangsu, Peoples R China
[3] Nanjing Normal Univ, Coll Chem & Mat Sci, Nanjing 210046, Jiangsu, Peoples R China
[4] Nanjing Univ, Inst Acoust, Key Lab Modern Acoust, Minist Educ, Nanjing 210093, Jiangsu, Peoples R China
来源
CHINESE SCIENCE BULLETIN | 2012年 / 57卷 / 01期
基金
中国国家自然科学基金;
关键词
tissue engineering scaffold; PLA foam; cell size; thermal gravimetric analysis; decomposition kinetic performance; IN-VITRO DEGRADATION; THERMAL-DEGRADATION; POLYMERIZATION; STABILITY; SCAFFOLDS;
D O I
10.1007/s11434-011-4873-5
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
A thermal gravimetric method is described for evaluating the kinetics of cell size-dependent decomposition and lifetime estimation for microcellular tissue engineering scaffolds made of biodegradable polylactic acid (PLA) foams. PLA foam cell sizes from 550 to 20 mu m were fabricated experimentally using a solvent-free solid-state foaming technique under saturation pressures from 1 to 5 MPa. The thermal properties of the PLA foams with respect to the cell sizes were measured using thermal gravimetric analysis in a nitrogen atmosphere and the activation energy and pre-exponential factor were derived to evaluate the decomposition kinetics and estimate lifetime. It was found that small cell sizes can be achieved under high saturation pressures and that the thermal stability of PLA decreases after the fabrication process. The cell size-dependent thermal stability and degradation rate indicate that a PLA foam of larger cell sizes has a shorter degradation time, a few tenths that of the PLA raw material, at a temperature of 37A degrees C. The results suggest that it is feasible to optimize fabrication parameters to obtain appropriate cell sizes and lifetimes that satisfy the application requirements for various organs. This study provides the basis for precise scaffold design and quantitative analysis of PLA foams in tissue engineering applications.
引用
收藏
页码:83 / 89
页数:7
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