Adhesion of Helicobacter pylori strains to alpha-2,3-linked sialic acids

被引：58

作者：

Hirmo, S

Kelm, S

Schauer, R

Nilsson, B

Wadstrom, T

机构：

[1] LUND UNIV,INST MED MICROBIOL,S-22362 LUND,SWEDEN

[2] CHRISTIAN ALBRECHTS UNIV KIEL,INST BIOCHEM,D-24098 KIEL,GERMANY

[3] NATL DEF RES ESTAB,DEPT NBC DEF,S-90182 UMEA,SWEDEN

来源：

GLYCOCONJUGATE JOURNAL | 1996年 / 13卷 / 06期

关键词：

sialic acid specificity; sialoside; haemagglutinin; H-pylori strains; derivatized erythrocytes;

D O I：

10.1007/BF01053196

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Helicobacter pylori is a human pathogen associated with gastritis and peptic ulcer. Adhesion properties of H. pylori to various structures have been described in the literature, including evidence for sialic acid-binding. To study the specificity and frequency of sialic acid-binding, fourteen H. pylori strains were investigated using haemagglutination with derivatised erythrocytes carrying sialic acids only on defined glycans and using haemagglutination inhibition assays. From these studies H. pylori strains can be grouped into sialic acid-dependent and sialic acid-independent classes. The sialic acid-dependent strains require alpha-2,3-linked sialic acid for haemagglutination. The potential roles of sialic acid-dependent adhesions for H. pylori-related infections are discussed.

引用

页码：1005 / 1011

页数：7