Intrauterine growth restriction is associated with persistent juxtamedullary expression of renin in the fetal kidney

被引:33
作者
Kingdom, JCP
Hayes, M
McQueen, J
Howatson, AG
Lindop, GBM [1 ]
机构
[1] Univ Glasgow, Western Infirm, Dept Pathol, Glasgow G11 6NT, Lanark, Scotland
[2] UCL, Dept Obstet & Gynaecol, London, England
[3] Univ Glasgow, Dept Obstet & Gynaecol, Glasgow G12 8QQ, Lanark, Scotland
[4] Royal Hosp Sick Children, Glasgow G3 8SJ, Lanark, Scotland
关键词
neonate kidney; growth retardation; renin gene expression; hypertension; prenatal environment; kidney development;
D O I
10.1046/j.1523-1755.1999.00295.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background. Intrauterine growth restriction (IUGR) has been linked to impaired renal function and hypertension, suggesting that an adverse prenatal environment could alter kidney development and renin production. Methods. Immunohistochemistry and in situ hybridization were employed to localize renin-containing cells (RCCs) in the deep, middle, and superficial zones of autopsy kidney sections, in parallel with histologic maturation, from unexplained stillborn fetuses of normal weight (N = 26) and stillborn fetuses with IUGR (N = 17). Results. In the control group, the number of RCC per 100 glomeruli in the deep zone decreased with advancing gestation from 40 at 20 weeks gestation to five at term (P < 0.001), whereas the opposite change was found in the superficial zone (increase from 5 per 100 to 55 per 100; P < 0.001). In the IUGR group, the density of RCCs in both the superficial and deep zones was similar to the control group at 20 weeks, and no shift in renin gene expression was observed as gestation advanced. Histologic maturation was unaltered. Conclusions. Renin gene expression persists and predominates in the deep renal cortex of the stillborn IUGR fetus, and could contribute to the pathogenesis of neonatal oliguria and/or hypertension during postnatal life.
引用
收藏
页码:424 / 429
页数:6
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