IGF-1, inflammation and stem cells: interactions during muscle regeneration

被引：203

作者：

Mourkioti, F ^{[1
]}

Rosenthal, N ^{[1
]}

机构：

[1] EMBL, Mouse Biol Unit, I-00016 Monterotondo, RM, Italy

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 10期

关键词：

D O I：

10.1016/j.it.2005.08.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Insulin-like growth factor-I (IGF-1) is an important mediator in numerous developmental processes, such as proliferation, differentiation, survival, growth, apoptosis and regeneration. Mouse genetics have provided important insights into the signalling mechanisms that are necessary for the coordination of muscle repair. Recent studies on the role of IGF-1 in the promotion of cell recruitment to the injured muscle and the subsequent resolution of the inflammatory response have unveiled new perspectives into local repair mechanisms.

引用

页码：535 / 542

页数：8

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