Connective tissue growth factor: A role in airway remodelling in asthma?

被引：23

作者：

Burgess, JK

机构：

[1] Univ Sydney, Dept Pharmacol, Sydney, NSW 2006, Australia

[2] Woolcock Inst Med Res, Sydney, NSW, Australia

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2005年 / 32卷 / 11期

关键词：

airway remodelling; asthma; connective tissue growth factor; transforming growth factor-beta;

D O I：

10.1111/j.1440-1681.2005.04296.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Severe persistent asthma is accompanied by structural changes in the airway, referred to as remodelling. The mechanisms driving airway remodelling are poorly understood. 2. Transforming growth factor (TGF)-beta is increased in the airways of patients with asthma. Many of the effects of TGF-beta are mediated by connective tissue growth factor (CTGF). 3. Overexpression of CTGF is linked to many fibrotic diseases, but its exact role in airway remodelling is unknown. 4. Connective tissue growth factor mediates cell adhesion, migration, proliferation, survival, extracellular matrix synthesis and has a role in angiogenesis. 5. Current asthma therapies do not inhibit CTGF induction. 6. Understanding the mechanisms underlying the role of CTGF in airway remodelling may lead to new therapeutic strategies for asthma.

引用

页码：988 / 994

页数：7

共 93 条

[21] Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin αvβ3 and heparan sulfate proteoglycan [J].