Microbial transformation of the diterpene mulin-11,13-dien-20-oic acid by Mucor plumbeus

被引：14

作者：

Areche, Cados ^{[1
]}

Loyola, Luis A. ^{[2
]}

Borquez, Jorge ^{[2
]}

Rovirosa, Juana ^{[1
]}

San-Martin, Aurelio ^{[1
]}

机构：

[1] Univ Chile, Fac Sci, Dept Chem, Santiago, Chile

[2] Univ Antofogasto, Fac Basic Sci, Dept Chem, Lab Nat Products, Antofagasta, Chile

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2008年 / 46卷 / 08期

关键词：

NMR; H-1; C-13; 2D NMR; Azorella compacta; biotransformation; diterpenoids; Mucor plumbeus; tyrosol;

D O I：

10.1002/mrc.2238

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Two new mulinane-type derivatives: 16-hydroxy mulin-11,13-dien-20-oic (2) acid and 7 alpha,16-dihydroxy mulin-11,13-dien-20-oic (3) acid were obtained by microbial transformation of mulin-11,13-dien-20-oic acid (1), along with tyrosol (4) using liquid cultures of Mucor plumbeus. The latter compound has not been previously identified in the genus Mucor. Structural elucidation of these metabolites was achieved using 1D- and 2D-NMR spectroscopy. Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：765 / 768

页数：4

共 30 条

[1]

[Anonymous], 2007, Dictionary of Natural Products on CD-ROM

[2]

MICROBIAL TRANSFORMATION OF DITERPENES - HYDROXYLATION OF SCLAREOL, MANOOL AND DERIVATIVES BY MUCOR-PLUMBEUS [J].