Interaction between FtsZ and inhibitors of cell division

被引:145
作者
Huang, J [1 ]
Cao, C [1 ]
Lutkenhaus, J [1 ]
机构
[1] UNIV KANSAS, MED CTR, DEPT MICROBIOL MOL GENET & IMMUNOL, KANSAS CITY, KS 66103 USA
关键词
D O I
10.1128/jb.178.17.5080-5085.1996
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The interaction between inhibitors of cell division and FtsZ were assessed by using the yeast two-hybrid system. An interaction was observed between FtsZ and SulA, a component of the SOS response, and the interacting regions were mapped to their conserved domains. This interaction was reduced by mutations in sulA and by most mutations in ftsZ that make cell refractory to sulA. No interaction was detected between FtsZ and MinCD, an inhibitory component of the site selection system. However, interactions were observed among various members of the Min system, and MinE was found to reduce the interaction between MinC and MinD. The implications of these findings for cell division are discussed.
引用
收藏
页码:5080 / 5085
页数:6
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