Protein stability: The COP9 signalosome gets in on the act

被引：26

作者：

Seeger, M

Gordon, C

Dubiel, W

机构：

[1] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Humboldt Univ, Dept Surg, Div Mol Biol, Fac Med Charite, D-10117 Berlin, Germany

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 16期

关键词：

D O I：

10.1016/S0960-9822(01)00382-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The COP9 signalosome is a multiprotein complex somewhat similar to the lid component of the 26S proteasome. Recent studies suggest that it regulates the stability of proteins by interfering with the ubiquitin-proteasome pathway via deneddylation and phosphorylation.

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页码：R643 / R646

页数：4

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