Functions of gelsolin: motility, signaling, apoptosis, cancer

被引：334

作者：

Kwiatkowski, DJ ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Div Hematol, Genet Lab, Boston, MA 02115 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0955-0674(99)80012-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Several new members of the gelsolin family have been discovered in the past year. Determination of the structure of gelsolin and identification of lysophosphatidic acid as a negative regulator provide novel functional insights. Gelsolin is an obligate downstream effector of Rac for motility in dermal fibroblasts, regulates phosphoinositide signaling pathways and ion channel function in vivo, and acts as both a regulator and effector of apoptosis.

引用

页码：103 / 108

页数：6

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