Functions of gelsolin: motility, signaling, apoptosis, cancer

被引：334

作者：

Kwiatkowski, DJ ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Div Hematol, Genet Lab, Boston, MA 02115 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0955-0674(99)80012-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Several new members of the gelsolin family have been discovered in the past year. Determination of the structure of gelsolin and identification of lysophosphatidic acid as a negative regulator provide novel functional insights. Gelsolin is an obligate downstream effector of Rac for motility in dermal fibroblasts, regulates phosphoinositide signaling pathways and ion channel function in vivo, and acts as both a regulator and effector of apoptosis.

引用

页码：103 / 108

页数：6

共 59 条

[21] Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines [J].

Geng, YJ ;

Azuma, T ;

Tang, JX ;

Hartwig, JH ;

Muszynski, M ;

Wu, Q ;

Libby, P ;

Kwiatkowski, DJ .

EUROPEAN JOURNAL OF CELL BIOLOGY, 1998, 77 (04) :294-302

[22] Tertiary structure of destrin and structural similarity between two actin-regulating protein families [J].

Hatanaka, H ;

Ogura, K ;

Moriyama, K ;

Ichikawa, S ;

Yahara, I ;

Inagaki, F .

CELL, 1996, 85 (07) :1047-1055

[23] Deconstructing gelsolin: identifying sites that mimic or alter binding to actin and phosphoinositides [J].

Janmey, PA ;

Stossel, TP ;

Allen, PG .

CHEMISTRY & BIOLOGY, 1998, 5 (04) :R81-R85

[24] A cloning method for caspase substrates that uses the yeast two-hybrid system: Cloning of the antiapoptotic gene gelsolin [J].

Kamada, S ;

Kusano, H ;

Fujita, H ;

Ohtsu, M ;

Koya, RC ;

Kuzumaki, N ;

Tsujimoto, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (15) :8532-8537

[25] Conformational changes in actin induced by its interaction with gelsolin [J].

Khaitlina, S ;

Hinssen, H .

BIOPHYSICAL JOURNAL, 1997, 73 (02) :929-937

[26] Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis [J].

Kothakota, S ;

Azuma, T ;

Reinhard, C ;

Klippel, A ;

Tang, J ;

Chu, KT ;

McGarry, TJ ;

Kirschner, MW ;

Koths, K ;

Kwiatkowski, DJ ;

Williams, LT .

SCIENCE, 1997, 278 (5336) :294-298

[27]

Kuzumaki N, 1998, MOL B INT U, P121

[28] PLASMA AND CYTOPLASMIC GELSOLINS ARE ENCODED BY A SINGLE GENE AND CONTAIN A DUPLICATED ACTIN-BINDING DOMAIN [J].

KWIATKOWSKI, DJ ;

STOSSEL, TP ;

ORKIN, SH ;

MOLE, JE ;

COLTEN, HR ;

YIN, HL .

NATURE, 1986, 323 (6087) :455-458

[29] Suppression of morphological transformation by radicicol is accompanied by enhanced gelsolin expression [J].

Kwon, HJ ;

Yoshida, M ;

Nagaoka, R ;

Obinata, T ;

Beppu, T ;

Horinouchi, S .

ONCOGENE, 1997, 15 (21) :2625-2631

[30] Gelsolin, a protein that caps the barbed ends and severs actin filaments, enhances the actin-based motility of Listeria monocytogenes in host cells [J].

Laine, RO ;

Phaneuf, KL ;

Cunningham, CC ;

Kwiatkowski, D ;

Azuma, T ;

Southwick, FS .

INFECTION AND IMMUNITY, 1998, 66 (08) :3775-3782

← 1 2 3 4 5 6 →