Molecular regulation of adult CNS neurogenesis: an integrated view

被引：161

作者：

Hagg, T ^{[1
]}

机构：

[1] Univ Louisville, Kentucky Spinal Cord Injury Res Ctr, Dept Neurol Surg, Louisville, KY 40292 USA

[2] Univ Louisville, Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA

来源：

TRENDS IN NEUROSCIENCES | 2005年 / 28卷 / 11期

关键词：

D O I：

10.1016/j.tins.2005.08.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neural stem cells in the adult subventricular zone and dentate gyrus might be utilized to replace lost neurons in neurological disorders. The development of treatments would be facilitated by identifying the mechanisms that contribute to functional neurogenesis in adult animals. This review focuses on the emerging view that localized and overlapping pathways of growth factors, metalloproteases, neurotransmitters and hormones regulate different aspects of neurogenesis within the neurogenic niches. Neuroblast migration is precisely regulated by cooperation between several repellants, attractants and guidance molecules that are located within specific CNS regions. Further elucidation of crucial molecular regulators and integration of their signaling cascades should lead to more rational and effective approaches to harness the exciting phenomenon of adult CNS neurogenesis.

引用

页码：589 / 595

页数：7

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