Postpartum-activation of multiple sclerosis is associated with down-regulation of tolerogenic HLA-G

被引：34

作者：

Airas, Laura

Nikula, Tuomas

Huang, Yu-Hwa

Lahesmaa, Riitta

Wiendl, Heinz

机构：

[1] Univ Turku, Dept Neurol, FIN-20521 Turku, Finland

[2] Univ Turku, MediCity Res Lab, FIN-20521 Turku, Finland

[3] Univ Turku, Natl Grad Sch Informat & Struct Biol, FIN-20521 Turku, Finland

[4] Univ Turku, Turku Ctr Biotechnol, FIN-20520 Turku, Finland

[5] Abo Akad Univ, FIN-20520 Turku, Finland

[6] Julius Maximilians Univ Wuerzburg, Dept Neurol, D-97080 Wurzburg, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 187卷 / 1-2期

基金：

芬兰科学院;

关键词：

multiple sclerosis; pregnancy; HLA-G; postpartum-activation; microarray;

D O I：

10.1016/j.jneuroim.2007.05.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We used microarray analysis to obtain insights into the immuno-regulatory mechanisms controlling pregnancy-associated MS disease activity. We studied expression levels of 5000 immune-related genes in peripheral blood mononuclear cells in patients with relapsing-remitting MS during pregnancy and postpartum and in comparison to controls. In the microarray analysis, HLA-G, a non-classical major histocornpatibility molecule mainly attributed with immune-tolerogenic functions, was found differentially regulated between MS patients and controls. The finding was corroborated and extended by real-time PCR, flow-cytometry and ELISA in a larger patient sample. The results delineate an important role for the immune-tolerogenic molecule HLA-G in modulating disease activity and pregnancy-related changes in MS patients. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：205 / 211

页数：7