Increased risk of respiratory tract infections in children with Down syndrome: the consequence of an altered immune system

被引：77

作者：

Bloemers, Beatrijs L. P. ^{[2
]}

Broers, Chantal J. M. ^{[1
]}

Bont, Louis ^{[2
]}

Weijerman, Michel E. ^{[1
]}

Gemke, Reinoud J. B. J. ^{[1
]}

van Furth, A. Marceline ^{[1
]}

机构：

[1] VU Univ Med Ctr Amsterdam, Dept Pediat, Div Pediat Infect Dis Immunol & Rheumatol, NL-1007 MB Amsterdam, Netherlands

[2] Univ Med Ctr Utrecht, Div Infect Dis, Dept Pediat, NL-3508 AB Utrecht, Netherlands

来源：

MICROBES AND INFECTION | 2010年 / 12卷 / 11期

关键词：

Down syndrome; Respiratory tract infections; Immunology; Innate immunity; Adaptive immunity; MIXED LYMPHOCYTE-REACTION; NECROSIS-FACTOR-ALPHA; SERUM THYMIC-FACTOR; ACUTE LUNG INJURY; T-CELL RESPONSE; SYNDROME TRISOMY-21; YOUNG-CHILDREN; INTERFERON-GAMMA; HEALTH-PROBLEMS; ANTIGEN LFA-1;

D O I：

10.1016/j.micinf.2010.05.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the influence of the immune system on the occurrence of respiratory tract infections in these children has never been reviewed. (C) 2010 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：799 / 808

页数：10

共 88 条

[11] DERANGEMENTS OF IMMUNOGLOBULIN LEVELS, PHYTOHEMAGGLUTININ RESPONSIVENESS AND T AND B CELL MARKERS IN DOWNS-SYNDROME AT DIFFERENT AGES [J].