Protective effects of ginseng components in a rodent model of neurodegeneration

被引:65
作者
Lian, XY
Zhang, ZZ
Stringer, JL
机构
[1] Baylor Coll Med, Dept Pharmacol, Houston, TX 77030 USA
[2] Stephen F Austin State Univ, Coll Forestry, Nacogdoches, TX 75962 USA
关键词
D O I
10.1002/ana.20450
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
To test the proposed neuroprotective activity of whole ginseng extract and its components, we used 3-nitropropionic acid (3-NP), an inhibitor of succinate dehydrogenase, to produce neurodegeneration. Treatment with 3-nitropropionic acid (90mg/kg) over a 5-day period resulted in severe impairment of movement and loss of neurons in the striatum. Pretreatment with a preparation from the whole root of American ginseng had no protective effects. Pretreatment with a preparation of ground leaves and stems, which contains greater levels of ginsenosides than ground root, improved the behavioral score and reduced the volume of the striatal lesion. A partial purification of American ginseng was performed to concentrate the putative protective components: Rb-1, Rb-3, and Rd (termed Rb extract). Pretreatment with the Rb extract significantly reduced the 3-nitropropionic acid-induced motor impairment and cell loss in the striatum, and it completely prevented any mortality. Significant effects on motor function, mortality, and the striatal lesion volume also were measured in animals pretreated with the individual ginscnosides, Rb-1, Rb-3, or Rd. The results demonstrate that some of the ginsenosides have neuroprotective activity, and that a partial purification of whole ginseng to concentrate the neuroprotective components may have utility as a neuroprotective agent.
引用
收藏
页码:642 / 648
页数:7
相关论文
共 29 条
[11]  
2-8
[12]   Antioxidant properties of a North American ginseng extract [J].
Kitts, DD ;
Wijewickreme, AN ;
Hu, C .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2000, 203 (1-2) :1-10
[13]   3-Nitropropionic acid induced in vivo protein oxidation in striatal and cortical synaptosomes: insights into Huntington's disease [J].
La Fontaine, MA ;
Geddes, JW ;
Banks, A ;
Butterfield, DA .
BRAIN RESEARCH, 2000, 858 (02) :356-362
[14]  
Lee WT, 2000, NEUROSCIENCE, V95, P89
[15]   HPLC determination of ginsenosides content in ginseng dietary supplements using ultraviolet detection [J].
Li, WK ;
Fitzloff, JF .
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2002, 25 (16) :2485-2500
[16]   Anticonvulsant activity of ginseng on seizures induced by chemical convulsants [J].
Lian, XY ;
Zhang, TZ ;
Stringer, JL .
EPILEPSIA, 2005, 46 (01) :15-22
[17]   Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro [J].
Liao, BS ;
Newmark, H ;
Zhou, RP .
EXPERIMENTAL NEUROLOGY, 2002, 173 (02) :224-234
[18]   Protection of ischemic hippocampal neurons by ginsenoside Rb-1, a main ingredient of ginseng root [J].
Lim, JH ;
Wen, TC ;
Matsuda, S ;
Tanaka, J ;
Maeda, N ;
Peng, H ;
Aburaya, J ;
Ishihara, K ;
Sakanaka, M .
NEUROSCIENCE RESEARCH, 1997, 28 (03) :191-200
[19]  
Ludolph A., 1992, NEURODEGENERATION, V1, P21
[20]   3-nitropropionic acid neurotoxicity: Visualization by silver staining and implications for use as an animal model of Huntington's disease [J].
Miller, PJ ;
Zaborszky, L .
EXPERIMENTAL NEUROLOGY, 1997, 146 (01) :212-229