The site-specific correction of genetic defects

被引：18

作者：

Strauss, M ^{[1
]}

机构：

[1] Humboldt Universitat Berlin, Max Delbruck Ctr Mol Med, D-13122 Berlin, Germany

[2] Danish Canc Soc, Inst Canc Biol, DK-2100 Copenhagen, Denmark

来源：

NATURE MEDICINE | 1998年 / 4卷 / 03期

关键词：

D O I：

10.1038/nm0398-274

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recently developed gene targeting procedure shows promise for the efficient correction of genetic defects in vivo but many questions have yet to be answered (pages 285–290).

引用

页码：274 / 275

页数：2

共 10 条

[1] A VERSATILE VECTOR FOR GENE AND OLIGONUCLEOTIDE TRANSFER INTO CELLS IN CULTURE AND IN-VIVO - POLYETHYLENIMINE [J].

BOUSSIF, O ;

LEZOUALCH, F ;

ZANTA, MA ;

MERGNY, MD ;

SCHERMAN, D ;

DEMENEIX, B ;

BEHR, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7297-7301

[2] Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide [J].

ColeStrauss, A ;

Yoon, KG ;

Xiang, YF ;

Byrne, BC ;

Rice, MC ;

Gryn, J ;

Holloman, WK ;

Kmiec, EB .

SCIENCE, 1996, 273 (5280) :1386-1389

[3]

DEGRUYTER W, 1997, CONCEPTS GENE THERAP

[4]

FANG WH, 1993, J BIOL CHEM, V268, P11838

[5] THE REC2 GENE ENCODES THE HOMOLOGOUS PAIRING PROTEIN OF USTILAGO-MAYDIS [J].

KMIEC, EB ;

COLE, A ;

HOLLOMAN, WK .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (11) :7163-7172

[6] MISMATCH REPAIR - MECHANISMS AND RELATIONSHIP TO CANCER SUSCEPTIBILITY [J].

KOLODNER, RD .

TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (10) :397-401

[7] In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides [J].

Kren, BT ;

Bandyopadhyay, P ;

Steer, CJ .

NATURE MEDICINE, 1998, 4 (03) :285-290

[8]

WU GY, 1991, J BIOL CHEM, V266, P14338

[9] Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA center dot DNA oligonucleotide [J].

Yoon, K ;

ColeStrauss, A ;

Kmiec, EB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (05) :2071-2076

[10] GENE TARGETING IN NORMAL AND AMPLIFIED CELL-LINES [J].

ZHENG, H ;

WILSON, JH .

NATURE, 1990, 344 (6262) :170-173

← 1 →