Aurora-A: the maker and breaker of spindle poles

被引:366
作者
Barr, Alexis R. [1 ]
Gergely, Fanni [1 ]
机构
[1] Univ Cambridge, Canc Res UK Cambridge Res Inst, Dept Oncol, Cambridge CB2 0RE, England
关键词
centrosome; mitosis; spindle;
D O I
10.1242/jcs.013136
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The gene encoding the Aurora-A protein kinase is located in the 20q13 breast cancer amplicon and is also overexpressed in colorectal, pancreatic and gastric tumours. Although Aurora-A may not be a bona fide oncoprotein in humans, it is a promising drug target in cancer therapy. Thus, it is surprising that so little is known of its role in normal cells. The primary function of Aurora-A is to promote bipolar spindle assembly, but the molecular details of this process remained obscure until recently. The discovery of several novel Aurora-A-binding proteins and substrates has implicated Aurora-A in centrosome maturation and separation, acentrosomal and centrosomal spindle assembly, kinetochore function, cytokinesis and in cell fate determination. Here we discuss recent advances in determining the early mitotic role of Aurora-A, with a strong emphasis on its function at the mitotic spindle poles.
引用
收藏
页码:2987 / 2996
页数:10
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