β-Hematin (Hemozoin) mediated decompostion of polyunsaturated fatty acids to 4-hydroxy-2-nonenal

被引：11

作者：

Miller, CM ^{[1
]}

Carney, CK ^{[1
]}

Schrimpe, AC ^{[1
]}

Wright, DW ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37235 USA

来源：

INORGANIC CHEMISTRY | 2005年 / 44卷 / 07期

关键词：

D O I：

10.1021/ic048821i

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

beta-Hematin is an important heme metabolite of malarial infection. Its role as an agent mediating the formation of the reactive electrophile 4-hydroxynonenal (HNE) from polyunsaturated fatty acids was investigated. In vitro formation of HNE was found to be facilitated by the presence of hemozoin in a concentration-dependent fashion. The reactivity of HNE derived from reaction with beta-hematin was confirmed through its ability to form protein adducts on myoglobin.

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页码：2134 / 2136

页数：3

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