Genetic adjuvants for DNA vaccines

被引：141

作者：

Scheerlinck, JPY ^{[1
]}

机构：

[1] Univ Melbourne, Ctr Anim Biotechnol, Melbourne, Vic 3010, Australia

来源：

VACCINE | 2001年 / 19卷 / 17-19期

关键词：

DNA vaccination; cytokine; targeting; chemokine; costimulatory molecules;

D O I：

10.1016/S0264-410X(00)00495-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The relatively low efficacy of DNA vaccines in inducing immune responses, especially in large animal species and humans. has impaired their practical use. Despite considerable effort expended on improving DNA vaccine delivery, only minute amounts of Ag are available for immune induction following DNA vaccination. Two complementary strategies have been used to improve and modulate the immune response induced by DNA vaccines: (i) supplementing DNA vaccines with plasmids encoding cytokines and (ii) targeting the Ag encoded by DNA vaccine through genetically fusing the Ag to molecules binding cell surface receptors. This paper reviews recent progress in these two areas and possible mechanisms responsible for the observed effects. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2647 / 2656

页数：10

共 72 条

[21]

Iwasaki A, 1997, J IMMUNOL, V158, P4591

[22]

Kim JJ, 1997, J IMMUNOL, V158, P816

[23] Antigen-specific humoral and cellular immune responses can be modulated in rhesus macaques through the use of IFN-γ, IL-12, or IL-18 gene adjuvants [J].

Kim, JJ ;

Nottingham, LK ;

Tsai, A ;

Lee, DJ ;

Maguire, HC ;

Oh, J ;

Dentchev, T ;

Manson, KH ;

Wyand, MS ;

Agadjanyan, MG ;

Ugen, KE ;

Weiner, DB .

JOURNAL OF MEDICAL PRIMATOLOGY, 1999, 28 (4-5) :214-223

[24] Cytokine molecular adjuvants modulate immune responses induced by DNA vaccine constructs for HIV-1 and SIV [J].

Kim, JJ ;

Simbiri, KA ;

Sin, JI ;

Dang, KS ;

Oh, J ;

Dentchev, T ;

Lee, D ;

Nottingham, LK ;

Chalian, AA ;

McCallus, D ;

Ciccarelli, R ;

Agadjanyan, MG ;

Weiner, DB .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 1999, 19 (01) :77-84

[25] Coadministration of IL-12 or IL-10 expression cassettes drives immune responses toward a Th1 phenotype [J].

Kim, JJ ;

Maguire, HC ;

Nottingham, LK ;

Morrison, LD ;

Tsai, A ;

Sin, JI ;

Chalian, AA ;

Weiner, DB .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 1998, 18 (07) :537-547

[26] Modulation of antigen-specific humoral responses in rhesus macaques by using cytokine cDNAs as DNA vaccine adjuvants [J].

Kim, JJ ;

Yang, JS ;

VanCott, TC ;

Lee, DJ ;

Manson, KH ;

Wyand, MS ;

Boyer, JD ;

Ugen, KE ;

Weiner, DB .

JOURNAL OF VIROLOGY, 2000, 74 (07) :3427-3429

[27]

Kim JJ, 1997, NAT BIOTECHNOL, V15, P641

[28]

Kim JJ, 1998, EUR J IMMUNOL, V28, P1089, DOI 10.1002/(SICI)1521-4141(199803)28:03<1089::AID-IMMU1089>3.0.CO

[29]

2-L

[30]

Kim JJ, 2000, J INTERF CYTOK RES, V20, P311

← 1 2 3 4 5 6 7 8 →