Role of regulatory T cells in allergy and asthma

被引：155

作者：

Akbari, O ^{[1
]}

Stock, P ^{[1
]}

DeKruyff, RH ^{[1
]}

Umetsu, DT ^{[1
]}

机构：

[1] Stanford Univ, Dept Pediat, Div Immunol & Allergy, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.coi.2003.09.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Th2 cells play a critical role in the pathogenesis of allergy and asthma. However, the immunological mechanisms that downmodulate and protect against the development of these disorders are poorly understood. A spectrum of CD4(+) T cells, including Th3 cells, T-R cells, CD4(+)CD25(+) cells and NKT cells play a critical role in regulating these diseases. A better understanding of the role of regulatory cells in allergic diseases may lead to the identification of novel therapeutic targets.

引用

页码：627 / 633

页数：7

共 76 条

[1] Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen [J].

Akbari, O ;

DeKruyff, RH ;

Umetsu, DT .

NATURE IMMUNOLOGY, 2001, 2 (08) :725-731

[2]

Akbari O, 2002, NAT MED, V8, P1024, DOI 10.1038/nm745

[3] Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity [J].

Akbari, O ;

Stock, P ;

Meyer, E ;

Kronenberg, M ;

Sidobre, S ;

Nakayama, T ;

Taniguchi, M ;

Grusby, MJ ;

DeKruyff, RH ;

Umetsu, DT .

NATURE MEDICINE, 2003, 9 (05) :582-588

[4] Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation [J].

Asano, M ;

Toda, M ;

Sakaguchi, N ;

Sakaguchi, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :387-396

[5] Mechanisms of disease: The effect of infections on susceptibility to autoimmune and allergic diseases [J].

Bach, JF .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (12) :911-920

[6] T cell regulation as a side effect of homeostasis and competition [J].

Barthlott, T ;

Kassiotis, G ;

Stockinger, B .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (04) :451-460

[7] CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity [J].

Belkaid, Y ;

Piccirillo, CA ;

Mendez, S ;

Shevach, EM ;

Sacks, DL .

NATURE, 2002, 420 (6915) :502-507

[8]

Braun-Fahrländer C, 1999, CLIN EXP ALLERGY, V29, P28, DOI 10.1046/j.1365-2222.1999.00479.x

[9] Environmental exposure to endotoxin and its relation to asthma in school-age children [J].

Braun-Fahrländer, C ;

Riedler, J ;

Herz, U ;

Eder, W ;

Waser, M ;

Grize, L ;

Maisch, S ;

Carr, D ;

Gerlach, F ;

Bufe, A ;

Lauener, RP ;

Schierl, R ;

Renz, H ;

Nowak, D ;

von Mutius, E .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (12) :869-877

[10] CD1d-mediated recognition of an α-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution [J].

Brossay, L ;

Chioda, M ;

Burdin, N ;

Koezuka, Y ;

Casorati, G ;

Dellabona, P ;

Kronenberg, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (08) :1521-1528

← 1 2 3 4 5 6 7 8 →