Role of regulatory T cells in allergy and asthma

被引：155

作者：

Akbari, O ^{[1
]}

Stock, P ^{[1
]}

DeKruyff, RH ^{[1
]}

Umetsu, DT ^{[1
]}

机构：

[1] Stanford Univ, Dept Pediat, Div Immunol & Allergy, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.coi.2003.09.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Th2 cells play a critical role in the pathogenesis of allergy and asthma. However, the immunological mechanisms that downmodulate and protect against the development of these disorders are poorly understood. A spectrum of CD4(+) T cells, including Th3 cells, T-R cells, CD4(+)CD25(+) cells and NKT cells play a critical role in regulating these diseases. A better understanding of the role of regulatory cells in allergic diseases may lead to the identification of novel therapeutic targets.

引用

页码：627 / 633

页数：7

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