Asymmetric nucleophilic addition to β- and γ-alkoxy aldehydes using carbohydrate as a chiral auxiliary

被引：9

作者：

Yoshida, T ^{[1
]}

Chika, J ^{[1
]}

Takei, H ^{[1
]}

机构：

[1] Tokyo Inst Technol, Interdisciplinary Grad Sch Sci & Engn, Midori Ku, Yokohama, Kanagawa 2268502, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(98)00717-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The nucleophilic addition of Grignard reagents and allyltributyltin to chiral omega-tetrahydropyranyloxy propanal and butanal derived from L-fucose and D-arabinose gave the corresponding alcohols with high diastereoselectivity (up to 51% de by 1,6-asymmetric induction and 95% de by 1,5-asymmetric induction). (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：4305 / 4308

页数：4

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