One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using boric acid as catalyst

被引：211

作者：

Tu, S ^{[1
]}

Fang, F ^{[1
]}

Miao, CB ^{[1
]}

Jiang, H ^{[1
]}

Feng, YJ ^{[1
]}

Shi, DQ ^{[1
]}

Wang, XS ^{[1
]}

机构：

[1] Xuzhou Normal Univ, Dept Chem, Key Lab Biotecnol Med Plant, Xuzhou 221009, Jiangsu, Peoples R China

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(03)01466-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives, using boric acid as catalyst, from aromatic aldehydes, 1.3-dicarbonyl compounds and urea in glacial acetic acid is described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields (86-97%) and short reaction time (0.5-2 h). (C) 2003 Elsevier Ltd. All rights reserved.

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页码：6153 / 6155

页数：3

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