Emerging roles for cyclooxygenase-2 in gastrointestinal mucosal defense

被引：127

作者：

Wallace, JL

Devchand, PR

机构：

[1] Univ Calgary, Dept Pharmacol & Therapeut, Mucosal Inflammat Res Grp, Calgary, AB T2N 4N1, Canada

[2] Harvard Univ, Sch Med, Div Cardiovasc, Ctr Excellence Vasc Med, Boston, MA USA

[3] Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2005年 / 145卷 / 03期

关键词：

cyclooxygenase; prostaglandin; ulcer; inflammation; lipoxin; nonsteroidal anti-inflammatory drugs; mucosal defense;

D O I：

10.1038/sj.bjp.0706201

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The development of selective inhibitors of cyclooxygenase-2 (COX-2) was based on the concept that this enzyme played little, if any, role in modulating the ability of the gastrointestinal (GI) tract to resist and respond to injury. There is now overwhelming evidence that this is far from true. Indeed, COX-2 mediates several of the most important components of 'mucosal defense', contributes significantly to the resolution of GI inflammation and plays a crucial role in regulating ulcer healing. COX-2 also contributes to long-term changes in GI function after bouts of inflammation. © 2005 Nature Publishing Group. All rights reserved.

引用

收藏

页码：275 / 282

页数：8

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