Proximal and distal gastric distension in normal subjects and H-pylori-positive and -negative dyspeptic patients and correlation with symptoms

Aim of the study was to analyze gastric distension with water in H. pylori-positive and -negative dyspeptic patients and normal subjects and the correlation with symptoms. Twenty dyspeptic patients and 19 normal subjects were studied. H. pylori was determined in each dyspeptic patient with the rapid urea test at endoscopy, Gastric distension was evaluated by real-time ultrasonography with the ingestion of stepwise-increasing amounts of water up to a total of 600 mi, During distension, the symptom score was evaluated as well. The proximal stomach was significantly smaller in dyspeptic patients than in healthy controls, at 100-600 mi water (P < 0.01), A larger distal stomach was observed at 500 and 600 mi of water (P < 0.01), The score of bloating and fullness was greater in dyspeptics than in controls at 300 and 600 mi of water distension. The symptoms score was linearly correlated with proximal and distal gastric measurements in dyspeptic patients and in controls, No significant difference was found in dyspeptic patients regarding the H. pylori status. In conclusion, dyspeptic patients show a defective adaptation of the whole stomach to water distension and an increased symptom perception score as compared to controls. H. pylori infection does not seem to be a determining factor in these observed findings.