The Twente Photoacoustic Mammoscope: system overview and performance

被引：177

作者：

Manohar, S ^{[1
]}

Kharine, A ^{[1
]}

van Hespen, JCG ^{[1
]}

Steenbergen, W ^{[1
]}

van Leeuwen, TG ^{[1
]}

机构：

[1] Univ Twente, Fac Sci & Technol, Biophys Engn Grp, NL-7500 AE Enschede, Netherlands

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2005年 / 50卷 / 11期

关键词：

D O I：

10.1088/0031-9155/50/11/007

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We present PAM, the Photoacoustic Mammoscope developed at the University of Twente, intended for initial retrospective clinical studies on subjects with breast tumours. A parallel plate geometry has been adopted and the breast will be gently compressed between a glass plate and a flat ultrasound detector matrix. Pulsed light (5 ns) from an Nd:YAG laser will impinge the breast through the glass plate in regions of interest; an appropriate number of the 590 elements of the detector matrix will be activated in succession to record photoacoustic signals. Three-dimensional image reconstruction employs a delay-and-sum beamforming algorithm. We discuss various instrumental aspects and the proposed imaging protocol. Performance studies of the Ultrasound detector are presented in terms of sensitivity, frequency response and resolution. Details of the patient-instrument interface are provided. Finally some imaging results on well-characterized breast tissue phantoms with embedded tumour simulating inserts are shown.

引用

页码：2543 / 2557

页数：15

共 25 条

[1]

*AM CANC SOC, 2004, BREAST CANC FACT FIG

[2] Detection of ultrawide-band ultrasound pulses in optoacoustic tomography [J].

Andreev, VG ;

Karabutov, AA ;

Oraevsky, AA .

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 2003, 50 (10) :1383-1390

[3]

FOLKMAN J, 2000, CANC MED, P132

[4] Time-domain optical mammography: initial clinical results on detection and characterization of breast tumors [J].

Grosenick, D ;

Moesta, KT ;

Wabnitz, H ;

Mucke, J ;

Stroszczynski, C ;

Macdonald, R ;

Schlag, PM ;

Rinneberg, H .

APPLIED OPTICS, 2003, 42 (16) :3170-3186

[5] Quantitative oximetry of breast tumors: a near-infrared method that identifies two optimal wavelengths for each tumor [J].

Heffer, EL ;

Fantini, S .

APPLIED OPTICS, 2002, 41 (19) :3827-3839

[6] Image reconstruction for photoacoustic scanning of tissue structures [J].

Hoelen, CGA ;

de Mul, FFM .

APPLIED OPTICS, 2000, 39 (31) :5872-5883

[7] Detection of photoacoustic transients originating from microstructures in optically diffuse media such as biological tissue [J].

Hoelen, CGA ;

Dekker, A ;

de Mul, FFM .

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 2001, 48 (01) :37-47

[8] Poly(vinyl alcohol) gels for use as tissue phantoms in photoacoustic mammography [J].

Kharine, A ;

Manohar, S ;

Seeton, R ;

Kolkman, RGM ;

Bolt, RA ;

Steenbergen, W ;

de Mul, FFM .

PHYSICS IN MEDICINE AND BIOLOGY, 2003, 48 (03) :357-370

[9] Thermoacoustic CT of the breast: Pilot study observations [J].

Kruger, RA ;

Kiser, WL .

BIOMEDICAL OPTOACOUSTICS II, 2001, 4256 :1-5

[10] Thermoacoustic CT of the breast [J].

Kruger, RA ;

Stantz, K ;

Kiser, WL .

MEDICAL IMAGING 2002: PHYSICS OF MEDICAL IMAGING, 2002, 4682 :521-525

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