The Role of MicroRNAs in Human Liver Cancers

被引：124

作者：

Braconi, Chiara ^{[2
]}

Henry, Jon C. ^{[2
]}

Kogure, Takayuki ^{[1
]}

Schmittgen, Thomas ^{[2
]}

Patel, Tushar ^{[1
]}

机构：

[1] Mayo Clin, Jacksonville, FL 32224 USA

[2] Ohio State Univ, Columbus, OH 43210 USA

来源：

SEMINARS IN ONCOLOGY | 2011年 / 38卷 / 06期

基金：

美国国家卫生研究院;

关键词：

TUMOR-SUPPRESSOR GENE; HEPATOCELLULAR-CARCINOMA; HEPATITIS-C; DOWN-REGULATION; UP-REGULATION; NONALCOHOLIC STEATOHEPATITIS; REGULATES EXPRESSION; MET PROTOONCOGENE; CHOLINE-DEFICIENT; CELL-MIGRATION;

D O I：

10.1053/j.seminoncol.2011.08.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver of global importance. Recent studies of the expression and role of microRNA (miRNA) in HCC are providing new insights into disease pathogenesis. In addition, therapeutic efforts targeting specific miRNAs are being evaluated in animal models of HCC. The potential of miRNAs as biomarkers of disease or prognostic markers is being explored. Herein, we review studies of miRNA expression in human HCC, and discuss recent advances in knowledge about the involvement and role of selected miRNAs in disease pathogenesis, as biomarkers, or as therapeutic targets for HCC. © 2011 Published by Elsevier Inc.

引用

页码：752 / 763

页数：12

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