Activity of a heat-induced reformulation of amphotericin B deoxycholate (Fungizone) against Leishmania donovani

被引：51

作者：

Petit, C

Yardley, V

Gaboriau, F

Bolard, J

Croft, SL

机构：

[1] Univ Paris 06, CNRS, ESA 7033, Lab Physicochim Biomol & Cellulaire, F-75252 Paris 05, France

[2] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 02期

关键词：

D O I：

10.1128/AAC.43.2.390

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The heat treatment of amphotericin B deoxycholate (Fungizone), which aas previously shown to induce superaggregation and decrease the toxicity of the drug to mammalian cells, increased its activity against Leishmania donovani in BALB/c mice, whereas it reduced its toxicity. Heat treatment preserved the activity of Fungizone against L. donovani HU3-infected mouse peritoneal macrophages.

引用

收藏

页码：390 / 392

页数：3

相关论文

共 28 条

[1] ANTILEISHMANIAL ACTIVITY OF LIPOSOME-ENCAPSULATED AMPHOTERICIN-B IN HAMSTERS AND MONKEYS [J].

BERMAN, JD ;

HANSON, WL ;

CHAPMAN, WL ;

ALVING, CR ;

LOPEZBERESTEIN, G .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (06) :847-851

[2] ACTIVITY OF AMPHOTERICIN-B CHOLESTEROL DISPERSION (AMPHOCIL) IN EXPERIMENTAL VISCERAL LEISHMANIASIS [J].

BERMAN, JD ;

KSIONSKI, G ;

CHAPMAN, WL ;

WAITS, VB ;

HANSON, WL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (09) :1978-1980

[3] Carrier effects on biological activity of amphotericin B [J].

Brajtburg, J ;

Bolard, J .

CLINICAL MICROBIOLOGY REVIEWS, 1996, 9 (04) :512-+

[4]

Croft Simon L., 1997, P245

[5] LIPOSOMAL AMPHOTERICIN-B IN THE TREATMENT OF VISCERAL LEISHMANIASIS [J].

CROFT, SL ;

DAVIDSON, RN ;

THORNTON, EA .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1991, 28 :111-118

[6] Short-course treatment of visceral leishmaniasis with liposomal amphotericin B (AmBisome) [J].

Davidson, RN ;

diMartino, L ;

Gradoni, L ;

Giacchino, R ;

Gaeta, GB ;

Pempinello, R ;

Scotti, S ;

Cascio, A ;

Castagnola, E ;

Maisto, A ;

Gramiccia, M ;

diCaprio, D ;

Wilkinson, RJ ;

Bryceson, ADM .

CLINICAL INFECTIOUS DISEASES, 1996, 22 (06) :938-943

[7]

DAVIDSON RN, 1994, Q J MED, V87, P75

[8] LIPOSOMAL AMPHOTERICIN-B IN DRUG-RESISTANT VISCERAL LEISHMANIASIS [J].

DAVIDSON, RN ;

CROFT, SL ;

SCOTT, A ;

MAINI, M ;

MOODY, AH ;

BRYCESON, ADM .

LANCET, 1991, 337 (8749) :1061-1062

[9]

DEMARIE S, 1994, J ANTIMICROB CHEMOTH, V33, P907

[10] TREATMENT OF BRAZILIAN KALA-AZAR WITH A SHORT-COURSE OF AMPHOCIL (AMPHOTERICIN-B CHOLESTEROL DISPERSION) [J].

DIETZE, R ;

MILAN, EP ;

BERMAN, JD ;

GROGL, M ;

FALQUETO, A ;

FEITOSA, TF ;

LUZ, KG ;

SUASSUNA, FAB ;

MARINHO, LAC ;

KSIONSKI, G .

CLINICAL INFECTIOUS DISEASES, 1993, 17 (06) :981-986