Percutaneous absorption of captorpil from hydrophilic cellulose gel(R) through excised rabbit skin and human skin

The purpose of this investigation was to design and evaluate the percutaneous absorption of captopril from a hydrophilic cellulose gel base(R). The effect of type and concentration of saturated fatty acids, amount of gel base as well as the concentration of drug on percutaneous absorption of captopril gel through rabbit skin were evaluated and selected to obtain some optimal formulations. Then the required flux (1488 mu g/h) for captopril transdermal drug delivery system to maintain the therapeutic minimum effective concentration through human skin was used to evaluate the development of the optimal formulations. The results indicated that these formulations containing 3, 5 and 10% captopril with 5% capric acid using 22.89, 6.98 and 4.89 cm(2) of administered area were attained to the therapeutic minimum effective concentration. Therefore these formulations were suitable for possible development of transdermal drug delivery system. Copyright (C) 1996 Elsevier Science B.V.