Beyond genomics

被引：14

作者：

Dollery, C. T. ^{[1
]}

机构：

[1] GlaxoSmithKline, Harlow, Essex, England

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2007年 / 82卷 / 04期

关键词：

D O I：

10.1038/sj.clpt.6100363

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The sequencing of the human genome has already had an enormous impact on medicine, particularly with single-gene changes that predispose to a serious disease such as cystic fibrosis or the overexpression of Her2 in about one-third of breast cancers. Genetic technology has led to some very important therapeutic innovations, including the use of imatinib mesylate ( Gleevec) in BCR-ABL chronic myeloid leukemia and of trastuzumab ( Herceptin) in Her2-positive breast cancer, but the much anticipated explosion of new effective treatments has been more modest than expected.

引用

页码：366 / 370

页数：6

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