Detection of mammaglobin expressing cells in blood of breast cancer patients

被引：49

作者：

Suchy, B ^{[1
]}

Austrup, F ^{[1
]}

Driesel, G ^{[1
]}

Eder, C ^{[1
]}

Kusiak, I ^{[1
]}

Uciechowski, P ^{[1
]}

Grill, HJ ^{[1
]}

Giesing, M ^{[1
]}

机构：

[1] Inst Mol Nanotechnol, D-45659 Recklinghausen, Germany

来源：

CANCER LETTERS | 2000年 / 158卷 / 02期

关键词：

human mammoglobin; disseminated cancer cells; blood; breast cancer; ovarian cancer; tumor cell lines;

D O I：

10.1016/S0304-3835(00)00520-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Expression of human mammaglobin (hMAM) was published to be exclusively expressed in mammary tissue, in solid tumors, axillary lymph nodes and disseminated cancer cells in blood of breast cancer patients. A quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) test was applied to investigate hMAM expression in blood of breast cancer patients. Mammaglobin mRNA expression was found not only in breast cancer cell lines but also in cell lines of other cancer origin. In our patient cohort hMAM expression in 11/98 (11%) samples of breast cancer and 3/12 (25%) ovarian cancer patients could be detected. hMAM mRNA expression as a candidate marker for the detection of disseminated cancer cells in blood of breast cancer patients showed low sensitivity and reduced tissue specificity. A prognostic significance of hMAM expression could not be demonstrated. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：171 / 178

页数：8

共 23 条

[1] Limitations of specific reverse-transcriptase polymerase chain reaction markers in the detection of metastases in the lymph nodes and blood of breast cancer patients [J].