Metal complexes in medicine: Design and mechanism of action

被引：113

作者：

Sadler, PJ ^{[1
]}

Guo, ZJ ^{[1
]}

机构：

[1] Univ Edinburgh, Dept Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

PURE AND APPLIED CHEMISTRY | 1998年 / 70卷 / 04期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1351/pac199870040863

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The application of inorganic chemistry to medicine ("Elemental Medicine") is a rapidly developing field, and novel therapeutic and diagnostic metal complexes are now having an impact on medical practice. Advances in biocoordination chemistry are crucial for improving the design of compounds to reduce toxic side-effects and understand their mechanisms of action. In this article, we focus on the chemistry of two key areas: the biotransformation of metal complexes and targeting, with particular reference to platinum anticancer, gold antiarthritic, and bismuth antiulcer drugs.

引用

页码：863 / 871

页数：9

共 57 条

[1] METAL-COMPOUNDS IN THERAPY AND DIAGNOSIS [J].

ABRAMS, MJ ;

MURRER, BA .

SCIENCE, 1993, 261 (5122) :725-730

[2] SYNTHESIS, STRUCTURE, AND SPECTROSCOPIC PROPERTIES OF BISMUTH CITRATE COMPOUNDS .1. CRYSTAL-STRUCTURES OF K5-X(NH4)X[BI2(CIT)2(HCIT)](H2O)Y (X = 0.25, Y = 13) AND (NH4)8[BI2(CIT)2(HCIT)2(H2O)4](H2O)2 [J].

ASATO, E ;

DRIESSEN, WL ;

DEGRAAFF, RAG ;

HULSBERGEN, FB ;

REEDIJK, J .

INORGANIC CHEMISTRY, 1991, 30 (22) :4210-4218

[3] SYNTHESIS, STRUCTURE, AND SPECTROSCOPIC CHARACTERIZATION OF BISMUTH CITRATE COMPOUNDS AND BISMUTH-CONTAINING ULCER HEALING AGENT COLLOIDAL BISMUTH SUBCITRATE (CBS) .3. CRYSTAL AND SOLUTION STRUCTURES OF K(NH4)[BI2(CIT)2(H2O)2](H2O)X (X=2,4) [J].

ASATO, E ;

KATSURA, K ;

MIKURIYA, M ;

FUJII, T ;

REEDIJK, J .

INORGANIC CHEMISTRY, 1993, 32 (23) :5322-5329

[4] L-METHIONINE INCREASES THE RATE OF REACTION OF 5'-GUANOSINE MONOPHOSPHATE WITH THE ANTICANCER DRUG CISPLATIN - MIXED-LIGAND ADDUCTS AND REVERSIBLE METHIONINE BINDING [J].

BARNHAM, KJ ;

DJURAN, MI ;

MURDOCH, PD ;

RANFORD, JD ;

SADLER, PJ .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1995, (22) :3721-3726

[5] [PT(CBDCA-O) (NH3)(2)(L-METHIONINE-S)] - RING-OPENED ADDUCT OF THE ANTICANCER-DRUG CARBOPLATIN (PARAPLATIN) - DETECTION OF A SIMILAR COMPLEX IN URINE BY NMR-SPECTROSCOPY [J].

BARNHAM, KJ ;

FREY, U ;

MURDOCH, PD ;

RANFORD, JD ;

SADLER, PJ ;

NEWELL, DR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (24) :11175-11176

[6] INTERMOLECULAR DISPLACEMENT OF S-BOUND L-METHIONINE ON PLATINUM(II) BY GUANOSINE 5'-MONOPHOSPHATE - IMPLICATIONS FOR THE MECHANISM OF ACTION OF ANTICANCER DRUGS [J].

BARNHAM, KJ ;

DJURAN, MI ;

MURDOCH, PD ;

SADLER, PJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (06) :721-722

[7] Stabilization of monofunctional platinum-nucleotide adducts: Reactions of N-acetyl-L-methionine complexes with guanosine 5'-monophosphate and guanylyl(3'-5')guanosine [J].

Barnham, KJ ;

Guo, ZJ ;

Sadler, PJ .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1996, (13) :2867-2876

[8] Solid-state carbon-13 nuclear magnetic resonance investigations of bismuth citrate complexes and crystal structure of Na-2[Bi-2(cit)(2)]center dot 7H(2)O [J].

Barrie, PJ ;

Djuran, MI ;

Mazid, MA ;

McPartlin, M ;

Sadler, PJ ;

Scowen, IJ ;

Sun, HZ .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1996, (12) :2417-2422

[9]

BARTON S, 1997, IN PRESS INORG CHIM

[10]

BARTON SJ, UNPUB

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