Study of lipophilic character of serotonergic ligands

The R(M) values of a series of serotonergic derivatives were measured using a reversed-phase TLC system with acetone, acetonitrile or methanol as the organic modifier of the mobile phase. As regards the basic aspects of the chromatographic technique, the series of compounds studied here behave in quite the same way as the previously investigated series of chemicals, i.e. a very good correlation is found between the experimental and extrapolated R(M) values as well as between the extrapolated R(M) values from different organic solvent systems; the relationship between intercepts and slopes of the TLC equations in series of congeneric compounds; the influence of the organic modifier on the slopes of the TLC equations. The R(M) values from the above system were shown to be correlated with those obtained with a C-18 high-performance TLC. Finally, both chromatographic parameters were compared with calculated octanol-water log P values.