Recurrent lacunar infarction following a previous lacunar stroke: a clinical study of 122 patients

被引:67
作者
Arboix, A. [1 ]
Font, A. [1 ]
Garro, C. [1 ]
Garcia-Eroles, L. [2 ]
Comes, E. [1 ]
Massons, J. [1 ]
机构
[1] Hosp Univ Sagrat Cor, Dept Neurol, Cerebrovasc Div, E-08029 Barcelona, Spain
[2] Hosp Univ Bellvitge, Lhospitalet Llobregat, Clin Informat Syst, Barcelona, Spain
关键词
D O I
10.1136/jnnp.2007.119776
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To determine clinical variables related to recurrent lacunar infarction following a previous lacunar stroke. Methods: A total of 122 out of 733 consecutive patients with lacunar infarction collected from a hospital based registry between 1986 and 2004 were readmitted because of a recurrent lacunar infarction. In a subset of 59 patients, cognition was assessed using the Mini-Mental State Examination (MMSE). Predictors of lacunar infarction recurrence were assessed by logistic regression analysis. Results: First lacunar infarction recurrence occurred in 101 patients (83%) and multiple recurrences in 21. The mean time between first ever lacunar infarction and recurrent lacunes was 58.3 months (range 2-240). In the subset of 59 patients in whom cognition was studied, cognitive impairment, defined as an MMSE score,24, was detected in 16% (8/49) of patients with first lacunar infarction recurrence and in 40% (4/10) of those with multiple lacunar infarction recurrences. In the multivariate analysis, hypertension (odds ratio 2.01, 95% CI 1.23 to 3.30) and diabetes (odds ratio 1.62, 95% CI 1.07 to 2.46) were significant predictors of lacunar stroke recurrence, whereas hyperlipidaemia was inversely associated (odds ratio 0.52, 95% CI 0.30 to 0.90). Conclusions: Hypertension and diabetes were significant factors related to recurrent lacunar infarction. Hyperlipidaemia appeared to have a protective role. Cognitive impairment was a frequent finding in patients with multiple lacunar infarction recurrences.
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页码:1392 / 1394
页数:3
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