Structure and neurotrophic activity of seco-prezizaane-type sesquiterpenes from Illicium merrillianum

被引：89

作者：

Huang, JM

Yokoyama, R

Yang, CS

Fukuyama, Y ^{[1
]}

机构：

[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Inst Pharmacognosy, Yamashiro, Tokushima 7708514, Japan

[2] Beijing Univ Chin Med, Fac Pharmaceut Sci, Beijing 100029, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 04期

关键词：

D O I：

10.1021/np0005715

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An extract of the pericarps of Illicium merrillianum has yielded four new sesquiterpenes: 3 alpha -hydroxycycloparvifloralone (1), 1,2-dehydrocycloparvifloralone (2), (11) 7,14-ortholactone-3 alpha -hydroxyfloridanolide (3), and 11-O-debenzoyltashironin (4) along with cycloparvifloralone (5), merrillianone (6), and tashironin (7). The structures of 1-4 were determined on the basis of spectroscopic analyses. 11-O-Debenzoyltashironin (4) showed neurotrophic activity in primary culture of rat cortical neurons at 0.1-10 muM. However, cycloparvifloralone-type sesquiterpenes (1, 2, 5, and 6) and tashironin (7) had no neurotrophic activity at these concentrations.

引用

页码：428 / 431

页数：4

共 12 条

[1] SERUM-FREE B27/NEUROBASAL MEDIUM SUPPORTS DIFFERENTIATED GROWTH OF NEURONS FROM THE STRIATUM, SUBSTANTIA-NIGRA, SEPTUM, CEREBRAL-CORTEX, CEREBELLUM, AND DENTATE GYRUS [J].