Merrilactone A, a novel neurotrophic sesquiterpene dilactone from Illicium merrillianum

被引：166

作者：

Huang, JM

Yokoyama, R

Yang, CS

Fukuyama, Y ^{[1
]}

机构：

[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Inst Pharmacognosy, Tokushima 7708514, Japan

[2] Beijing Univ Chinese Med, Fac Pharmaceut Sci, Beijing 100029, Peoples R China

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 32期

关键词：

Illicium merrillianum; sesquiterpene lactone; merrilactone A; structure elucidation; neurotrophic activity;

D O I：

10.1016/S0040-4039(00)01023-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Merrilactone A, isolated from the pericarps of Illicium merrillianum, shows an intriguing neurotrophic activity in the cultures of fetal rat cortical neurons. Its structure has been elucidated to be a unique sesquiterpene bearing two gamma-lactones and an oxetane ring by extensive analyses of spectral data and then confirmed by X-ray crystallographic analysis. Further, the absolute configuration has been established by the modified Mosher's method. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：6111 / 6114

页数：4

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