STRUCTURES OF AMERICANOL-A AND ISOAMERICANOL-A HAVING A NEUROTROPHIC PROPERTY FROM THE SEEDS OF PHYTOLACCA-AMERICANA

被引：65

作者：

FUKUYAMA, Y ^{[1
]}

HASEGAWA, T ^{[1
]}

TODA, M ^{[1
]}

KODAMA, M ^{[1
]}

OKAZAKI, H ^{[1
]}

机构：

[1] OTSUKA PHARMACEUT CO LTD, TOKUSHIMA 77101, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 01期

关键词：

AMERICANOL-A; ISOAMERICANOL-A; AMERICANIN-A; ISOAMERICANIN-A; NEO-LIGNAN; 1,4-BENZODIOXANE; PHYTOLACCA-AMERICANA; PHYTOLACCACEAE; CHOLINE ACETYLTRANSFERASE; NEUROTROPHIC ACTIVITY;

D O I：

10.1248/cpb.40.252

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structures of new neo-lignans, isoamericanol A (1) and americanol A (2) isolated from the seeds of Phytolacca americana have been elucidated on the basis of spectroscopic data and then confirmed by chemical correlation with the previously known isoamericanin A (3) and americanin A (4). Isoamericanol A, americanol A, and americanin A have been found to enhance choline acetyltransferase activity at 10(-5) M in a cultured neuronal cell system derived from fetal rat hemisphere.

引用

页码：252 / 254

页数：3

共 13 条

[1]

ANTUS S, 1986, LIEBIGS ANN CHEM, P647

[2] MITOTIC NEUROBLASTS IN DISSOCIATED CELL-CULTURES FROM EMBRYONIC RAT CEREBRAL HEMISPHERES EXPRESS NEUROFILAMENT PROTEIN [J].