Chemotaxis of human CD4+eosinophils

被引：7

作者：

Okubo, Y ^{[1
]}

Tsukadaira, A ^{[1
]}

Takashi, S ^{[1
]}

Kubo, K ^{[1
]}

Koyama, S ^{[1
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Internal Med 1, Matsumoto, Nagano 3908621, Japan

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2001年 / 125卷

关键词：

CD4; eosinophil; chemotaxis TNF-alpha;

D O I：

10.1159/000053847

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We reviewed the biological functions of CD4+ eosinophils, which are observed in peripheral blood, sputum and bronchoalveotar lavage fluid of various diseases. We have shown that CD4 molecules on human eosinophils are induced by tumor necrosis factor-alpha (TNF-alpha) stimulation. Interleukin-16 (IL-16) has been reported to bind a natural soluble ligand for the CD4 molecule. We reported that TNF-alpha -stimulated eosinophils migrate in a time- and dose-dependent manner against IL-16. Theophylline and dexamethasone significantly inhibited CD4 expression. Theophylline inhibited CD4+ eosinophil chemotaxis, but dexamethasone did not. Theophylline may prevent airway inflammation by downregulating the expression of CD4 molecule and CD4+ eosinophil migration. However, dexamethasone may inhibit airway inflammation through the downregulation of CD4 expression. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：19 / 21

页数：3

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