The inhibitory principle of lipopolysaccharide-induced nitric oxide production from Inula britannica var. chinensis

被引：35

作者：

Je, KH

Han, AR

Lee, HT

Mar, W

Seo, EK ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Pharm, Nat Prod Chem Lab, Seoul 120750, South Korea

[2] Seoul Natl Univ, Coll Pharm, Inst Nat Prod Res, Seoul 110460, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 01期

关键词：

Inula britannica L. var. chinensis (Rupr.) Reg; Compositae; 1-O-acetyl-4R; 6S-britannilactone; iNOS inhibitor;

D O I：

10.1007/BF02980051

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A sesquiterpene lactone, 1-O-acetyl-4R,6S-britannilactone (1) isolated from the flowers of Inula britannica L. var. chinensis (Rupr.) Reg. (Compositae), was found as an NOS inhibitory constituent for the first time with an IC50 value of 22.1 muM which is more potent than the positive control, L-N-6-(1-iminoethyl)lysine (IC50 = 33.7 muM). Structure of compound 1 was identified by 1D and 2D NMR experiments and by comparison with the reference standard.

引用

页码：83 / 85

页数：3

共 15 条

[1]

Bensky D., 1993, CHINESE HERBAL MED M, P193

[2]

DAWSON TM, 1994, J NEUROSCI, V14, P5147

[3]

ANALYSIS OF NITRATE, NITRITE, AND [N-15]-LABELED NITRATE IN BIOLOGICAL-FLUIDS [J].